In: Journal of Visual Experiments, 2012, vol. 62, p. e3666
The mammalian heart is incapable of significant regeneration following an acute injury such as myocardial infarction. By contrast, urodele amphibians and teleost fish retain a remarkable capacity for cardiac regeneration with little or no scarring throughout life. It is not known why only some non-mammalian vertebrates can recreate a complete organ from remnant tissues. To understand the...
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In: Development, 2012, vol. 139, p. 1921-1930
Mammals respond to a myocardial infarction by irreversible scar formation. By contrast, zebrafish are able to resolve the scar and to regenerate functional cardiac muscle. It is not known how opposing cellular responses of fibrosis and new myocardium formation are spatially and temporally coordinated during heart regeneration in zebrafish. Here, we report that the balance between the reparative...
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In: BMC Developmental Biology, 2011, vol. 11, p. 21
Background: In humans, myocardial infarction is characterized by irreversible loss of heart tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele amphibians are capable of heart regeneration after a partial amputation. However, due to the lack of a suitable infarct model, it is not known how these animals respond to myocardial infarction.Results: Here, we have...
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In: Development, 2010, vol. 137, p. 871-879
In mammals, the loss of a limb is irreversible. By contrast, urodele amphibians and teleost fish are capable of nearly perfect regeneration of lost appendages. This ability depends on direct interaction between the wound epithelium and mesenchymal progenitor cells of the blastema. It has been known for decades that contact between the wound epithelium and the underlying blastema is essential for...
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