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International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

Condoluci, Adalgisa ; Terzi di Bergamo, Lodovico ; Langerbeins, Petra ; Hoechstetter, Manuela A. ; Herling, Carmen D. ; De Paoli, Lorenzo ; Delgado, Julio ; Rabe, Kari G. ; Gentile, Massimo ; Doubek, Michael ; Mauro, Francesca R. ; Chiodin, Giorgia ; Mattsson, Mattias ; Bahlo, Jasmin ; Cutrona, Giovanna ; Kotaskova, Jana ; Deambrogi, Clara ; Smedby, Karin E. ; Spina, Valeria ; Bruscaggin, Alessio ; Wu, Wei ; Moia, Riccardo ; Bianchi, Elena ; Gerber, Bernhard ; Zucca, Emanuele ; Gillessen, Silke ; Ghielmini, Michele ; Cavalli, Franco ; Stussi, Georg ; Hess, Mark A. ; Baumann, Tycho S. ; Neri, Antonino ; Ferrarini, Manlio ; Rosenquist, Richard ; Forconi, Francesco ; Foà, Robin ; Pospisilova, Sarka ; Morabito, Fortunato ; Stilgenbauer, Stephan ; Döhner, Hartmut ; Parikh, Sameer A. ; Wierda, William G. ; Montserrat, Emili ; Gaidano, Gianluca ; Hallek, Michael ; Rossi, Davide

In: Blood, 2020, vol. 135, no. 21, p. 1859–1869

Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients...