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γδ T cells kill Plasmodium falciparum in a granzyme- and granulysin-dependent mechanism during the late blood stage

Hernández-Castañeda, Maria Andrea ; Happ, Katharina ; Cattalani, Filippo ; Wallimann, Alexandra ; Blanchard, Marianne ; Fellay, Isabelle ; Scolari, Brigitte ; Lannes, Nils ; Mbagwu, Smart Ikechukwu ; Fellay, Benoît ; Filgueira, Luis ; Mantel, Pierre-Yves ; Walch, Michael

In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809

Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...