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    2 results 1
    Université de Fribourg

    Compartment and cell-type specific hypoxia responses in the developing Drosophila brain

    Baccino-Calace, Martin ; Prieto, Daniel ; Cantera, Rafael ; Egger, Boris

    In: Biology Open, 2020, vol. 9, no. 8, p. -

    Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that...

    Université de Fribourg

    A genetically encoded biosensor for visualising hypoxia responses in vivo

    Misra, Tvisha ; Baccino-Calace, Martin ; Meyenhofer, Felix ; Rodriguez-Crespo, David ; Akarsu, Hatice ; Armenta-Calderón, Ricardo ; Frei, Thomas A. Gorr, Christian ; Cantera, Rafael ; Egger, Boris ; Luschnig, Stefan

    In: Biology Open, 2017, vol. 6, no. 2, p. 296–304

    Cells experience different oxygen concentrations depending on location, organismal developmental stage, and physiological or pathological conditions. Responses to reduced oxygen levels (hypoxia) rely on the conserved hypoxia-inducible factor 1 (HIF-1). Understanding the developmental and tissue-specific responses to changing oxygen levels has been limited by the lack of adequate tools for...

    2 results 1