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Compartment and cell-type specific hypoxia responses in the developing Drosophila brain

Baccino-Calace, Martin ; Prieto, Daniel ; Cantera, Rafael ; Egger, Boris

In: Biology Open, 2020, vol. 9, no. 8, p. -

Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that...

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A genetically encoded biosensor for visualising hypoxia responses in vivo

Misra, Tvisha ; Baccino-Calace, Martin ; Meyenhofer, Felix ; Rodriguez-Crespo, David ; Akarsu, Hatice ; Armenta-Calderón, Ricardo ; Frei, Thomas A. Gorr, Christian ; Cantera, Rafael ; Egger, Boris ; Luschnig, Stefan

In: Biology Open, 2017, vol. 6, no. 2, p. 296–304

Cells experience different oxygen concentrations depending on location, organismal developmental stage, and physiological or pathological conditions. Responses to reduced oxygen levels (hypoxia) rely on the conserved hypoxia-inducible factor 1 (HIF-1). Understanding the developmental and tissue-specific responses to changing oxygen levels has been limited by the lack of adequate tools for...

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