Université de Fribourg

Uninephrectomy-induced lipolysis and low-grade inflammation are mimicked by unilateral renal denervation

Arsenijevic, Denis ; Cajot, Jean-François ; Fellay, Benoit ; Dulloo, Abdul G. ; Vliet, Bruce N. Van ; Montani, Jean-Pierre

In: Integrative Physiology, 2016, p. 227

Uninephrectomy (UniNX) in rats on a fixed food intake leads to increased lipolysis and a low-grade inflammation with an increased subset of circulating cytokines. Because UniNX ablates renal nerves on the side of the removed kidney, we tested the contribution of unilateral renal denervation in the phenotype of UniNX. We compared Sham-operated controls, left nephrectomy (UniNX) and unilateral...