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Specific ion channels control sensory gain, sensitivity, and kinetics in a tonic thermonociceptor

Saro, Gabriella ; Lia, Andrei-Stefan ; Thapliyal, Saurabh ; Marques, Filipe ; Busch, Karl Emanuel ; Glauser, Dominique A.

In: Cell Reports, 2020, vol. 30, no. 2, p. 397-408.e4

Pain sensation and aversive behaviors entail the activation of nociceptor neurons, whose function is largely conserved across animals. The functional heterogeneity of nociceptors and ethical concerns are challenges for their study in mammalian models. Here, we investigate the function of a single type of genetically identified C. elegans thermonociceptor named FLP. Using calcium imaging in...