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Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Prior, Larissa J. ; Eikelis, Nina ; Armitage, James A. ; Davern, Pamela J. ; Burke, Sandra L. ; Montani, Jean-Pierre ; Barzel, Benjamin ; Head, Geoffrey A.

In: Hypertension, 2010, p. -

The activation of the sympathetic nervous system through the central actions of the adipokine leptin has been suggested as a major mechanism by which obesity contributes to the development of hypertension. However, direct evidence for elevated sympathetic activity in obesity has been limited to muscle. The present study examined the renal sympathetic nerve activity and cardiovascular effects of a...