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Dexamethasone induces changes in osteogenic differentiation of human mesenchymal stromal cells via SOX9 and PPARG, but not RUNX2

Della Bella, Elena ; Buetti-Dinh, Antoine ; Licandro, Ginevra ; Ahmad, Paras ; Basoli, Valentina ; Alini, Mauro ; Stoddart, Martin J.

In: International journal of molecular sciences, 2021, vol. 22, no. 9, p. 16

Despite the huge body of research on osteogenic differentiation and bone tissue engineering, the translation potential of in vitro results still does not match the effort employed. One reason might be that the protocols used for in vitro research have inherent pitfalls. The synthetic glucocorticoid dexamethasone is commonly used in protocols for trilineage differentiation of human bone marrow...