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Autologous adult cortical cell transplantation enhances functional recovery following unilateral lesion of motor cortex in primates: a pilot study

Kaeser, Melanie ; Brunet, Jean-Francois ; Wyss, Alexander ; Belhaj-Saif, Abderraouf ; Liu, Yu ; Hamadjida, Adjia ; Rouiller, Eric M. ; Bloch, Jocelyne

In: Neurosurgery, 2011, vol. 68, no. 5, p. 1405-1417

BACKGROUND: Although cell therapy is a promising approach after cerebral cortex lesion, few studies assess quantitatively its behavioral gain in nonhuman primates. Furthermore, implantations of fetal grafts of exogenous stem cells are limited by safety and ethical issues.OBJECTIVE: To test in nonhuman primates the transplantation of autologous adult neural progenitor cortical cells with...