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Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

Talarek, Nicolas ; Cameroni, Elisabetta ; Jaquenoud, Malika ; Luo, Xuan ; Bontron, Séverine ; Lippman, Soyeon ; Devgan, Geeta ; Snyder, Michael ; Broach, James R. ; De Virgilio, Claudio

In: Molecular Cell, 2010, vol. 38, no. 3, p. 345-355

Eukaryotic cell proliferation is controlled by growth factors and essential nutrients, in the absence of which cells may enter into a quiescent (G0) state. In yeast, nitrogen and/or carbon limitation causes downregulation of the conserved TORC1 and PKA signaling pathways and, consequently, activation of the PAS kinase Rim15, which orchestrates G0 program initiation and ensures proper life span by...