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Pfm-like enzymes are a novel family of subclass b2 metallo-β-lactamases from Pseudomonas synxantha belonging to the Pseudomonas fluorescens complex

Poirel, Laurent ; Palmieri, Mattia ; Brilhante, Michael ; Masseron, Amandine ; Perreten, Vincent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 2, p. -

A carbapenem-resistant Pseudomonas synxantha isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-β- lactamase shared 71% amino acid identity with β-lactamase Sfh-1 from Serratia fonticola. The blaPFM-1 gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial ...