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Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy

Hasler, Gregor ; Buchmann, Andreas ; Haynes, Melanie ; Müller, Sabrina Theresia ; Ghisleni, Carmen ; Brechbühl, Sarela ; Tuura, Ruth

In: Translational Psychiatry, 2019, vol. 9, no. 1, p. 170

There is growing evidence for GABA and glutamate–glutamine dysfunction in the pathogenesis of mood and anxiety disorders. It is important to study this pathology in the early phases of the illness in order to develop new approaches to secondary prevention. New magnetic resonance spectroscopy (MRS) measures allow determining glutamine, the principal metabolite of synaptic glutamate that is...