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Zebrafish caudal fin angiogenesis assay—advanced quantitative assessment including 3-way correlative microscopy

Hlushchuk, Ruslan ; Brönnimann, Daniel ; Shokiche, Carlos Correa ; Schaad, Laura ; Triet, Ramona ; Jazwinska, Anna ; Tschanz, Stefan A. ; Djonov, Valentin

In: PLOS ONE, 2016, vol. 11, no. 3, p. e0149281

Background: Researchers evaluating angiomodulating compounds as a part of scientific projects or pre-clinical studies are often confronted with limitations of applied animal models. The rough and insufficient early-stage compound assessment without reliable quantification of the vascular response counts, at least partially, to the low transition rate to clinics. Objective: To establish an...