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Subcellular structural plasticity caused by the absence of the fast Ca²⁺ buffer calbindin D-28k in recurrent collaterals of cerebellar Purkinje neurons

Orduz, David ; Boom, Alain ; Gall, David ; Brion, Jean-Pierre ; Schiffmann, Serge N. ; Schwaller, Beat

In: Frontiers in Cellular Neuroscience, 2014, vol. 8, p. 364

Purkinje cells (PC) control spike timing of neighboring PC by their recurrent axon collaterals. These synapses underlie fast cerebellar oscillations and are characterized by a strong facilitation within a time window of <20 ms during paired-pulse protocols. PC express high levels of the fast Ca²⁺ buffer protein calbindin D-28k (CB). As expected from the absence of a fast Ca²⁺ buffer,...