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SV40-induced expression of calretinin protects mesothelial cells from asbestos cytotoxicity and may be a key factor contributing to mesothelioma pathogenesis

Henzi, Thomas ; Blum, Walter-Vincent ; Pfefferli, Martine ; Kawecki, Tadeusz J. ; Salicio, Valérie ; Schwaller, Beat

In: American Journal of Pathology, 2009, vol. 174, p. 2324-2336

The calcium-binding protein calretinin has emerged as a useful marker for the identification of mesotheliomas of the epithelioid and mixed types, but its putative role in tumor development has not been addressed previously. Although exposure to asbestos fibers is considered the main cause of mesothelioma, undoubtedly, not all mesothelioma patients have a history of asbestos exposure. The question...