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    2 results 1
    Université de Fribourg

    Mechanism of cystathionine-β-synthase inhibition by disulfiram : The role of bis(N,N-diethyldithiocarbamate)-copper(II)

    Zuhra, Karim ; Panagaki, Theodora ; B.Randi, Elisa ; Augsburger, Fiona ; Blondel, Marc ; Friocourt, Gaelle ; Herault, Yann ; Szabo, Csaba

    In: Biochemical Pharmacology, 2020, vol. 182, p. 114267

    Background: Hydrogen sulfide (H2S) is an endogenous mammalian gasotransmitter. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3- mercaptopyruvate sulfurtransferase (3-MST) are the principal enzymes responsible for its biogenesis. A recent yeast screen suggested that disulfiram (a well-known inhibitor of aldehyde dehydrogenase and a clinically used drug in the treatment of...

    Université de Fribourg

    Protein folding activity of ribosomal rna is a selective target of two unrelated antiprion drugs

    Tribouillard-Tanvier, Déborah ; Reis, Suzana Dos ; Gug, Fabienne ; Voisset, Cécile ; Béringue, Vincent ; Sabate, Raimon ; Kikovska, Ema ; Talarek, Nicolas ; Bach, Stéphane ; Huang, Chenhui ; Desban, Nathalie ; Saupe, Sven J. ; Supattapone, Surachai ; Thuret, Jean-Yves ; Chédin, Stéphane ; Vilette, Didier ; Galons, Hervé ; Sanyal, Suparna ; Blondel, Marc

    In: PLoS ONE, 2008, vol. 3, no. 5, p. e2174

    Background: 6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also active against mammalian prion in several cell-based assays and in vivo in a mouse model for prion-based diseases.Methodology/Principal Findings: Here we report the...

    2 results 1