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Short-term functional adaptation of aquaporin-1 surface expression in the proximal tubule, a component of glomerulotubular balance

Pohl, Marcus ; Shan, Qixian ; Petsch, Thomas ; Styp-Rekowska, Beata ; Matthey, Patricia ; Bleich, Markus ; Bachmann, Sebastian ; Theilig, Franziska

In: Journal of the American Society of Nephrology, 2014, p. ASN.2014020148

Transepithelial water flow across the renal proximal tubule is mediated predominantly by aquaporin-1 (AQP1). Along this nephron segment, luminal delivery and transepithelial reabsorption are directly coupled, a phenomenon called glomerulotubular balance. We hypothesized that the surface expression of AQP1 is regulated by fluid shear stress, contributing to this effect. Consistent with this...