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TASmania: A bacterial Toxin-Antitoxin Systems database

Akarsu, Hatice ; Bordes, Patricia ; Mansour, Moise ; Bigot, Donna-Joe ; Genevaux, Pierre ; Falquet, Laurent

In: PLOS Computational Biology, 2019, vol. 15, no. 4, p. e1006946

Bacterial Toxin-Antitoxin systems (TAS) are involved in key biological functions including plasmid maintenance, defense against phages, persistence and virulence. They are found in nearly all phyla and classified into 6 different types based on the mode of inactivation of the toxin, with the type II TAS being the best characterized so far. We have herein developed a new in silico discovery...