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3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

Abdollahi Govar, Armita ; Törő, Gábor ; Szaniszlo, Peter ; Pavlidou, Athanasia ; Bibli, Sofia‐Iris ; Thanki, Ketan ; Resto, Vicente A. ; Chao, Celia ; Hellmich, Mark R. ; Szabo, Csaba ; Papapetropoulos, Andreas ; Módis, Katalin

In: British Journal of Pharmacology, 2020, vol. 177, no. 4, p. 866–883

During angiogenesis, quiescent endothelial cells (ECs) are activated by various stimuli to form new blood vessels from pre‐existing ones in physiological and pathological conditions. Many research groups have shown that hydrogen sulfide (H2S), the newest member of the gasotransmitter family, acts as a proangiogenic factor. To date, very little is known about the regulatory role of...