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Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Belaunzaran, Osiris Marroquin ; Cordero, Maria Isabel ; Setola, Veronica ; Bianchi, Siro ; Galli, Carmela ; Bouche, Nicolas ; Mlynarik, Vladimir ; Gruetter, Rolf ; Sandi, Carmen ; Bensadoun, Jean-Charles ; Molinari, Maurizio ; Aebischer, Patrick

In: Plos one, 2011, vol. 6, no. 4, p. e18268

Background: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic. Methodology and Principal Findings: We report a novel method for the long-term ...

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Gaugler, Meret ; Genc, Ozgur ; Bobela, Wojciech ; Mohanna, Safa ; Ardah, Mustafa ; El-Agnaf, Omar ; Cantoni, Marco ; Bensadoun, Jean-Charles ; Schneggenburger, Ralf ; Knott, Graham ; Aebischer, Patrick ; Schneider, Bernard

In: Acta Neuropathologica, 2012, vol. 123, no. 5, p. 653-669