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Combined with anti‐Nogo‐A antibody treatment, BDNF did not compensate the extra deleterious motor effect caused by large size cervical cord hemisection in adult macaques

Beaud, Marie‐Laure ; Rouiller, Eric M. ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Schmidlin, Eric

In: CNS Neuroscience & Therapeutics, 2019, p. cns.13213

In spinal cord injured adult mammals, neutralizing the neurite growth inhibitor Nogo‐A with antibodies promotes axonal regeneration and functional recovery, although axonal regeneration is limited in length. Neurotrophic factors such as BDNF stimulate neurite outgrowth and protect axotomized neurons. Can the effects obtained by neutralizing Nogo‐A, inducing an environment favorable for...