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Acr-23 encodes a Monepantel-sensitive channel in Caenorhabditis elegans

Rufener, Lucien ; Bedoni, Nicola ; Baur, Roland ; Rey, Samantha ; Glauser, Dominique A. ; Bouvier, Jacques ; Beech, Robin ; Sigel, Erwin ; Puoti, Alessandro

In: PLoS Pathog, 2013, vol. 9, no. 8, p. e1003524

Monepantel is a member of the recently identified class of anthelmintics known as the amino-acetonitrile derivatives (AADs). Monepantel controls all major gastro-intestinal nematodes in sheep including those that are resistant to the classical anthelmintics. Previous studies have shown that the Caenorhabditis elegans acr-23 and the Haemonchus contortus Hco-mptl-1 genes may be prominent targets of...