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Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson

Zabrocki, Piotr ; Bastiaens, Ilse ; Delay, Charlotte ; Bammens, Tine ; Ghillebert, Ruben ; Pellens, Klaartje ; Virgilio, Claudio De ; Leuven, Fred Van ; Winderickx, Joris

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008, vol. 1783, no. 10, p. 1767-1780

Parkinson's disease is a neurodegenerative disorder characterized by the formation of Lewy bodies containing aggregated α-synuclein. We used a yeast model to screen for deletion mutants with mislocalization and enhanced inclusion formation of α-synuclein. Many of the mutants were affected in functions related to vesicular traffic but especially mutants in endocytosis and vacuolar degradation...