Université de Fribourg

Biophysics of temporal interference stimulation

Mirzakhalili, Ehsan ; Barra, Beatrice ; Capogrosso, Marco ; Lempka, Scott F.

In: Cell Systems, 2020, vol. 11, no. 6, p. 557-572.e5

Temporal interference (TI) is a non-invasive neurostimulation technique that utilizes high-frequency external electric fields to stimulate deep neuronal structures without affecting superficial, off-target structures. TI represents a potential breakthrough for treating conditions, such as Parkinson’s disease and chronic pain. However, early clinical work on TI stimulation was met with mixed...

Université de Fribourg

Spatiotemporal maps of proprioceptive inputs to the cervical spinal cord during three-dimensional reaching and grasping

Kibleur, Pierre ; Tata, Shravan R. ; Greiner, Nathan ; Conti, Sara ; Barra, Beatrice ; Zhuang, Katie ; Kaeser, Melanie ; Ijspeert , Auke ; Capogrosso, Marco

In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2020, vol. 28, no. 7, p. 1668–1677

Proprioceptive feedback is a critical component of voluntary movement planning and execution. Neuroprosthetic technologies aiming at restoring movement must interact with it to restore accurate motor control. Optimization and design of such technologies depends on the availability of quantitative insights into the neural dynamics of proprioceptive afferents during functional movements....

Université de Fribourg

Soft, implantable bioelectronic interfaces for translational research

Schiavone, Giuseppe ; Fallegger, Florian ; Kang, Xiaoyang ; Barra, Beatrice ; Vachicouras, Nicolas ; Roussinova, Evgenia ; Furfaro, Ivan ; Jiguet, Sébastien ; Seáñez, Ismael ; Borgognon, Simon ; Rowald, Andreas ; Li, Qin ; Qin, Chuan ; Bézard, Erwan ; Bloch, Jocelyne ; Courtine, Grégoire ; Capogrosso, Marco ; Lacour, Stéphanie P.

In: Advanced Materials, 2020, vol. 32, no. 17, p. 1906512

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐ based innovation toward clinical use calls for further advances in materials, manufacturing and characterization paradigms, and design rules. Herein, a ...

Université de Fribourg

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Petrini, Francesco M. ; Mazzoni, Alberto ; Rigosa, Jacopo ; Giambattistelli, Federica ; Granata, Giuseppe ; Barra, Beatrice ; Pampaloni, Alessandra ; Guglielmelli, Eugenio ; Zollo, Loredana ; Capogrosso, Marco ; Micera, Silvestro ; Raspopovic, Stanisa

In: BioMedical Engineering OnLine, 2019, vol. 18, no. 1, p. 44

The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent...