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NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response

Oberson, Anne ; Spagnuolo, Lorenzo ; Puddinu, Viola ; Barchet, Winfried ; Rittner, Karola ; Bourquin, Carole

In: Oncotarget, 2018, vol. 9, no. 5, p. -

Novel adjuvants are needed to increase the efficacy of vaccine formulations and immune therapies for cancer and chronic infections. In particular, adjuvants that promote a strong type I IFN response are required, since this cytokine is crucial for the development of efficient anti-tumoral and anti-viral immunity. Nucleic acid band 2 (NAB2) is a double- stranded RNA molecule isolated from...