Université de Fribourg

68Ga-NODAGA-RGDyK for αvβ3 integrin PET imaging : Preclinical investigation and dosimetry

Buchegger, F. ; Viertl, D. ; Baechler, Sébastien ; Dunet, V. ; Kosinski, M. ; Poitry-Yamate, C. ; Rüegg, Curzio ; Prior, J. O.

In: Nuklearmedizin, 2011, vol. 50, no. 6, p. 221-246

Ziel: Zur Darstellung von Integrin αvβ3 von Tumoren oder Tumorneugefäßen wählten wir das zyklische Bindungspeptid Arg-Gly-Asp-D-Tyr-Lys (RGDyK) gekoppelt an NODAGA zur Markierung mit 68Ga. Methoden: NODAGA-RGDyK (ABX) wurde mit dem 68Ga-Eluat des 68Ge-Generators IGG100 markiert mit der Prozessoreinheit PharmTracer. Bioverteilungen wurden in weiblichen Hsd-Mäusen 10, 30, 60 und 90 min nach...

Université de Fribourg

Two non-destructive neutron inspection techniques : prompt gamma-ray activation analysis and cold neutron tomography

Baechler, Sébastien ; Dousse, Jean-Claude (Dir.) ; Jolie, Jan (Codir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1381.

Two non-destructive inspection techniques employing both cold neutron beams have been developed at the Swiss spallation source SINQ of the Paul Scherrer Institute: (1) prompt gamma-ray activation analysis (PGAA) and (2) neutron tomography. PGAA is a nuclear analytical method for identifying and quantifying simultaneously the elements contained in a sample. The technique consists in detecting...

Université de Fribourg

The cold neutron tomography set-up at SINQ

Materna, T. ; Baechler, Sébastien ; Jolie, J. ; Masschaele, B. ; Dierick, M. ; Kardjilov, N.

In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2004, vol. 525, p. 69-73

The cold neutron tomography station operated at SINQ (Paul Scherrer Institute, Switzerland) is reviewed. The high neutron flux together with a set-up based on a scintillator screen and a CCD camera yielded fast and effective results with resolution down to 250 μm: tomography of small samples (up to 2 cm large) could be performed in less than an hour. The use of a velocity selector improved the...