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A puzzle of life: crafting ribosomal subunits

Kressler, Dieter ; Hurt, Ed ; Baßler, Jochen

In: Trends in Biochemical Sciences, 2017, p. -

The biogenesis of eukaryotic ribosomes is a complicated process during which the transcription, modification, folding, and processing of the rRNA is coupled with the ordered assembly of ∼80 ribosomal proteins (r-proteins). Ribosome synthesis is catalyzed and coordinated by more than 200 biogenesis factors as the preribosomal subunits acquire maturity on their path from the nucleolus to the...

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The power of AAA-ATPases on the road of pre-60S ribosome maturation — Molecular machines that strip pre-ribosomal particles

Kressler, Dieter ; Hurt, Ed ; Bergler, Helmut ; Baßler, Jochen

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011, p. -

The biogenesis of ribosomes is a fundamental cellular process, which provides the molecular machines that synthesize all cellular proteins. The assembly of eukaryotic ribosomes is a highly complex multi-step process that requires more than 200 ribosome biogenesis factors, which mediate a broad spectrum of maturation reactions. The participation of many energy-consuming enzymes (e.g. AAA-type...

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