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Silver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts

Aurore, Valerie ; Caldana, Fabienne ; Blanchard, Marianne ; Kharoubi Hess, Solange ; Lannes, Nils ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: Nanomedicine: Nanotechnology, Biology and Medicine, 2018, vol. 14, no. 2, p. 601–607

Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its...