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Removal of a subset of non-essential genes fully attenuates a highly virulent mycoplasma strain

Jores, Joerg ; Ma, Li ; Ssajjakambwe, Paul ; Schieck, Elise ; Liljander, Anne ; Chandran, Suchismita ; Stoffel, Michael H. ; Cippa, Valentina ; Arfi, Yonathan ; Assad-Garcia, Nacyra ; Falquet, Laurent ; Sirand-Pugnet, Pascal ; Blanchard, Alain ; Lartigue, Carole ; Posthaus, Horst ; Labroussaa, Fabien ; Vashee, Sanjay

In: Frontiers in Microbiology, 2019, vol. 10, p. -

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essential genes encoding, among others, potential virulence traits. Five genomic regions, representing...