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Eradication of a multidrug-resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom made, lytic bacteriophage preparation

Corbellino, Mario ; Kieffer, Nicolas ; Kutateladze, Mzia ; Balarjishvili, Nana ; Leshkasheli, Lika ; Askilashvili, Lia ; Tsertsvadze, George ; Rimoldi, Sara Giordana ; Nizharadze, Deia ; Hoyle, Naomi ; Nadareishvili, Lia ; Antinori, Spinello ; Pagani, Cristina ; Scorza, Daniele Giuseppe ; Romanò, Ai Ling Loredana ; Ardizzone, Sandro ; Danelli, Piergiorgio ; Gismondo, Maria Rita ; Galli, Massimo ; Nordmann, Patrice ; Poirel, Laurent

In: Clinical Infectious Diseases, 2020, vol. 70, no. 9, p. 1998–2001

In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.