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The soil microbiota harbors a diversity of carbapenem-hydrolyzing β-lactamases of potential clinical relevance

Gudeta, Dereje Dadi ; Bortolaia, Valeria ; Amos, Greg ; Wellington, Elizabeth M. H. ; Brandt, Kristian K. ; Poirel, Laurent ; Nielsen, Jesper Boye ; Westh, Henrik ; Guardabassi, Luca

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 1, p. 151–160

The origin of carbapenem-hydrolyzing metallo-β-lactamases (MBLs) acquired by clinical bacteria is largely unknown. We investigated the frequency, host range, diversity, and functionality of MBLs in the soil microbiota. Twenty-five soil samples of different types and geographical origins were analyzed by antimicrobial selective culture, followed by phenotypic testing and expression of...