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Intragenic alternative splicing coordination is essential for Caenorhabditis elegans slo-1 gene function

Glauser, Dominique A. ; Johnson, Brandon E. ; Aldrich, Richard W. ; Goodman, Miriam B.

In: Proceedings of the National Academy of Sciences, 2011, vol. 108, no. 51, p. 20790-20795

Alternative splicing is critical for diversifying eukaryotic proteomes, but the rules governing and coordinating splicing events among multiple alternate splice sites within individual genes are not well understood. We developed a quantitative PCR-based strategy to quantify the expression of the 12 transcripts encoded by the Caenorhabditis elegans slo-1 gene, containing three alternate splice...