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Initial viral inoculum determines kinapse-and synapse-like t cell motility in reactive lymph nodes

Sivapatham, Sujana ; Ficht, Xenia ; Albuquerque, Juliana Barreto de ; Page, Nicolas ; Merkler, Doron ; Stein, Jens V.

In: Frontiers in Immunology, 2019, vol. 10, p. -

T cell activation in lymphoid tissue occurs through interactions with cognate peptide- major histocompatibility complex (pMHC)-presenting dendritic cells (DCs). Intravital imaging studies using ex vivo peptide-pulsed DCs have uncovered that cognate pMHC levels imprint a wide range of dynamic contacts between these two cell types. T cell—DC interactions vary between transient,...