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Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

Pausch, Patrick ; Singh, Ujjwala ; Ahmed, Yasar Luqman ; Pillet, Benjamin ; Murat, Guillaume ; Altegoer, Florian ; Stier, Gunter ; Thoms, Matthias ; Hurt, Ed ; Sinning, Irmgard ; Bange, Gert ; Kressler, Dieter

In: Nature Communications, 2015, vol. 6, p. 7494

Exponentially growing yeast cells produce every minute >160,000 ribosomal proteins. Owing to their difficult physicochemical properties, the synthesis of assembly-competent ribosomal proteins represents a major challenge. Recent evidence highlights that dedicated chaperone proteins recognize the N-terminal regions of ribosomal proteins and promote their soluble expression and delivery to the...