Université de Fribourg

Large-scale comparison of toxin and antitoxins in Listeria monocytogenes

Agüero, José Antonio ; Akarsu, Hatice ; Aguilar-Bultet, Lisandra ; Oevermann, Anna ; Falquet, Laurent

In: Toxins, 2020, vol. 12, no. 1, p. 29

Toxin–antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in Listeria monocytogenes (Lm), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania...

Université de Fribourg

DeltaRpkm: an R package for a rapid detection of differential gene presence between related bacterial genomes

Akarsu, Hatice ; Aguilar-Bultet, Lisandra ; Falquet, Laurent

In: BMC Bioinformatics, 2019, vol. 20, no. 1, p. 621

Comparative genomics has seen the development of many software performing the clustering, polymorphism and gene content analysis of genomes at different phylogenetic levels (isolates, species). These tools rely on de novo assembly and/or multiple alignments that can be computationally intensive for large datasets. With a large number of similar genomes in particular, e.g., in surveillance and...

Université de Fribourg

Genetic separation of Listeria monocytogenes causing central nervous system infections in animals

Aguilar-Bultet, Lisandra ; Nicholson, Pamela ; Rychener, Lorenz ; Dreyer, Margaux ; Goezel, Bulent ; Origgi, Francesco C. ; Oevermann, Anna ; Frey, Joachim ; Falquet, Laurent

In: Frontiers in Cellular and Infection Microbiology, 2018, vol. 8, p. -

Listeria monocytogenes is a foodborne pathogen that causes abortion, septicemia, gastroenteritis and central nervous system (CNS) infections in ruminants and humans. L. monocytogenes strains mainly belong to two distinct phylogenetic groups, named lineages I and II. In general, clinical cases in humans and animals, in particular CNS infections, are caused by lineage I strains, while most of...

Université de Fribourg

Draft Genome sequence of the virulent avibacterium paragallinarum serotype a strain JF4211 and identification of two toxins

Aguilar-Bultet, Lisandra ; Calderon-Copete, Sandra P. ; Frey, Joachim ; Falquet, Laurent

In: Genome Announcements, 2013, vol. 1, no. 4, p. e00592-13

Avibacterium paragallinarum is an important pathogen of chicken livestock causing infectious coryza. Here, we report the draft genome sequence of the virulent A. paragallinarum serotype A strain JF4211 (2.8 Mbp and G+C content of 41%) and the two toxin operons discovered from the annotation of the genome.