In: Acta Astronautica, 2011, vol. 68, no. 9-10, p. 1589-1594
Passive head up tilt (HUT) and mental arithmetic (MA) are commonly used for providing mental and orthostatic challenges, respectively. In animal experiments, even a single exposure to a stressor has been shown to modify the response to subsequent stress stimulus. We investigated whether MA applied before HUT elicits synergistic responses in orthostatic heart rate (HR), cardiac output (CO),...
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In: Frontiers in Physiology, 2018, vol. 9, p. -
Aim: Red wine is usually ingested as an unmixed drink. However, mixtures of wine with juices and/or sucrose (mixed wine) are becoming more and more popular and could be ingested at either cold or hot temperature. Although the temperature effects on the cardiovascular system have been described for water and tea, with greater energy expenditure (EE) and lower cardiac workload with a colder...
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In: International Journal of Obesity, 2004, vol. 28, p. S58-65
In humans and most animal models, the development of obesity leads not only to increased fat depots in classical adipose tissue locations but also to significant lipid deposits within and around other tissues and organs, a phenomenon known as ectopic fat storage. The purpose of this review is to explore the possible locations of ectopic fat in key target-organs of cardiovascular control (heart,...
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In: American Journal of Physiology - Renal Physiology, 2014, vol. 306, no. 1, p. F130–F137
Although the kidney is believed to play a minor role in bile acid (BA) excretion, chronic renal failure (CRF) has been reported to be associated with increased serum bile acid levels and alterations in BA homeostasis. The mechanisms for elevated BA levels are poorly understood in both clinical and experimental studies. This study was designed to examine the effects of naturally progressing CRF of...
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In: Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry, 2007, vol. 7, no. 2, p. 137-141
Clinical and experimental studies provide increasing evidence that obesity is a major cardiovascular risk factor and that the adipose tissue is not just for regulation of lipid and energy homeostasis. Accordingly, the endocrine secretion of adipose tissue is implicated in the pathogenesis of vascular diseases. Whilst the functions of visceral and subcutaneous adipose tissue are relatively...
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In: Advances in Nutrition, 2016, vol. 7, no. 5, p. 950-960
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In: PLOS ONE, 2016, vol. 11, no. 3, p. e0151552
There is increasing recognition about the importance of enhancing energy expenditure (EE) for weight control through increases in low-intensity physical activities comparable with daily life (1.5–4 METS). Whole-body vibration (WBV) increases EE modestly and could present both a useful adjuvant for obesity management and tool for metabolic phenotyping. However, it is unclear whether a...
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In: Journal of Visualized Experiments, 2016, no. 108, p. -
Endothelium-derived nitric oxide (NO) produced from endothelial NO-synthase (eNOS) is one of the most important vasoprotective molecules in cardiovascular physiology. Dysfunctional eNOS such as uncoupling of eNOS leads to decrease in NO bioavailability and increase in superoxide anion (O₂.−) production, and in turn promotes cardiovascular diseases. Therefore, appropriate...
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In: Hypertension, 2010, p. -
The activation of the sympathetic nervous system through the central actions of the adipokine leptin has been suggested as a major mechanism by which obesity contributes to the development of hypertension. However, direct evidence for elevated sympathetic activity in obesity has been limited to muscle. The present study examined the renal sympathetic nerve activity and cardiovascular effects of a...
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In: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2008, vol. 294, p. R730-R737
Brown, Clive M.; Division of Physiology, Department of Medicine, University of Fribourg, Switzerland Dulloo, Abdul G.; Division of Physiology, Department of Medicine, University of Fribourg, Switzerland Yepuri, Gayathri; Division of Physiology, Department of Medicine, University of Fribourg, Switzerland Montani, and Jean-Pierre; Division of Physiology, Department of Medicine, University of...
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