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Université de Fribourg

Reliability of low‐power cycling efficiency in energy expenditure phenotyping of inactive men and women

Fares, Elie-Jacques ; Isacco, Laurie ; Monnard, Cathriona R. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Physiological Reports, 2017, vol. 5, no. 9, p. e13233

Standardized approaches to assess human energy expenditure (EE) are well defined at rest and at moderate to high‐intensity exercise, but not at light intensity physical activities energetically comparable with those of daily life (i.e., 1.5–4 times the resting EE, i.e., 1.5–4 METs). Our aim was to validate a graded exercise test for assessing the energy cost of low‐intensity dynamic...

Université de Fribourg

Energy expenditure and substrate oxidation in response to side-alternating whole body vibration across three commonly-used vibration frequencies

Fares, Elie-Jacques ; Charrière, Nathalie ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G. ; Miles-Chan, Jennifer L.

In: PLOS ONE, 2016, vol. 11, no. 3, p. e0151552

There is increasing recognition about the importance of enhancing energy expenditure (EE) for weight control through increases in low-intensity physical activities comparable with daily life (1.5–4 METS). Whole-body vibration (WBV) increases EE modestly and could present both a useful adjuvant for obesity management and tool for metabolic phenotyping. However, it is unclear whether a...

Université de Fribourg

Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters

Gai, Zhibo ; Chu, Lei ; Hiller, Christian ; Arsenijevic, Denis ; Penno, Carlos A. ; Montani, Jean-Pierre ; Odermatt, Alex ; Kullak-Ublic, Gerd A.

In: American Journal of Physiology - Renal Physiology, 2014, vol. 306, no. 1, p. F130–F137

Although the kidney is believed to play a minor role in bile acid (BA) excretion, chronic renal failure (CRF) has been reported to be associated with increased serum bile acid levels and alterations in BA homeostasis. The mechanisms for elevated BA levels are poorly understood in both clinical and experimental studies. This study was designed to examine the effects of naturally progressing CRF of...

Université de Fribourg

Cardiovascular and metabolic responses to tap water ingestion in young humans: does the water temperature matter?

Girona, M. ; Grasser, Erik Konrad ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Acta Physiologica, 2014, vol. 211, no. 2, p. 358–370

Aim: Drinking water induces short-term cardiovascular and metabolic changes. These effects are considered to be triggered by gastric distension and osmotic factors, but little is known about the influence of water temperature.Methods: We determined, in a randomized crossover study, the acute cardiovascular and metabolic responses to 500 mL of tap water at 3 °C (cold), 22 °C (room) and...

Université de Fribourg

Interaction of mental and orthostatic stressors

Goswami, Nandu ; Lackner, Helmut K. ; Papousek, Ilona ; Jezova, Daniela ; Montani, Jean-Pierre ; Hinghofer-Szalkay, Helmut G.

In: Acta Astronautica, 2010, p. -

We assessed hemodynamic responses induced by orthostatic and mental stressors, using passive head up tilt (HUT) and mental arithmetic (MA), respectively. The 15 healthy males underwent three protocols: (1) HUT alone, (2) MA in supine position and (3) MA+HUT, with sessions randomized and ≥2 weeks apart. In relation to baseline, HUT increased heart rate (HR) (+20.4±7.1 bpm; p<0.001),...

Université de Fribourg

Rate of cardiovascular recovery to combined or separate orthostatic and mental challenges

Goswami, Nandu ; Lackner, Helmut Karl ; Papousek, Ilona ; Jezova, Daniela ; Hinghofer-Szalkay, Helmut ; Montani, Jean-Pierre

In: International Journal of Psychophysiology, 2010, vol. 75, no. 1, p. 54-62

Post stress neurovascular responses induced by physical and mental stress are poorly understood. We investigated the time course of cardiovascular and autonomic recovery, induced by orthostatic and mental challenge, using passive head up tilt (HUT) and mental arithmetic (MA), respectively, when applied singly (MA, HUT) or in combination (MA + HUT). Fifteen healthy males participated in three...

Université de Fribourg

Orthostatic intolerance in older persons: etiology and countermeasures

Goswami, Nandu ; Blaber, Andrew P. ; Hinghofer-Szalkay, Helmut ; Montani, Jean-Pierre

In: Frontiers in Physiology, 2017, vol. 8, p. -

Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest immobilization, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Given that older patients spend up to...

Université de Fribourg

Does mental arithmetic before head up tilt have an effect on the orthostatic cardiovascular and hormonal responses?

Goswami, Nandu ; Lackner, Helmut Karl ; Papousek, Ilona ; Montani, Jean-Pierre ; Jezova, Daniela ; Hinghofer-Szalkay, Helmut G.

In: Acta Astronautica, 2011, vol. 68, no. 9-10, p. 1589-1594

Passive head up tilt (HUT) and mental arithmetic (MA) are commonly used for providing mental and orthostatic challenges, respectively. In animal experiments, even a single exposure to a stressor has been shown to modify the response to subsequent stress stimulus. We investigated whether MA applied before HUT elicits synergistic responses in orthostatic heart rate (HR), cardiac output (CO),...