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Partial splenectomy in the era of minimally invasive surgery: the current laparoscopic and robotic experiences

Balaphas, Alexandre ; Buchs, Nicolas ; Meyer, Jeremy ; Hagen, Monika ; Morel, Philippe

In: Surgical Endoscopy, 2015, vol. 29, no. 12, p. 3618-3627

Platelet transforming growth factor-β1 induces liver sinusoidal endothelial cells to secrete interleukin-6

Balaphas, Alexandre ; Meyer, Jeremy ; Perozzo, Remo ; Zeisser-Labouebe, Magali ; Berndt, Sarah ; Turzi, Antoine ; Fontana, Pierre ; Scapozza, Leonardo ; Gonelle-Gispert, Carmen ; Bühler, Leo H.

In: Cells, 2020, vol. 9, no. 5, p. 1311

The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleukin-6 (IL-6), a cytokine implicated in the early phase of liver regeneration....

Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation

Meyer, Jeremy ; Balaphas, Alexandre ; Fontana, Pierre ; Morel, Philippe ; Robson, Simon C. ; Sadoul, Karin ; Gonelle-Gispert, Carmen ; Bühler, Léo

In: Cells, 2020, vol. 9, no. 5, p. 1243

Background: Platelets were postulated to constitute the trigger of liver regeneration. The aim of this study was to dissect the cellular interactions between the various liver cells involved in liver regeneration and to clarify the role of platelets. (2) Methods: Primary mouse liver sinusoidal endothelial cells (LSECs) were co-incubated with increasing numbers of resting platelets, activated...

Impact of an intra-abdominal cooling device during open kidney transplantation in pigs

Longchamp, Alban ; Meier, Raphael P. H. ; Colucci, Nicola ; Balaphas, Alexandre ; Orci, Lorenzo A. ; Nastasi, Antonio ; Longchamp, Grgoire ; Moll, Solange ; Klauser, Antoine ; Pascual, Manuel ; Lazeyras, Franois ; Corpataux, Jean-Marc ; Bühler, Leo

In: Swiss Medical Weekly, 2019, vol. 149, no. 5152, p. -

Transplantation of kidneys from deceased donors is still associated with a high rate of postoperative renal dysfunction. During implantation into the recipient, the kidney rewarms. This second warm ischaemia time, which is not monitored, is harmful especially if prolonged. We recently developed an intra-abdominal cooling device that efficiently prevents kidney rewarming during robotic...