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    Université de Fribourg

    Internal lamellar and inverse hexagonal liquid crystalline phases during the digestion of krill and astaxanthin oil-in-water emulsions

    Yaghmur, Anan ; Lotfi, Saleh ; Ariabod, Sarah Atoussa ; Bor, Gizem ; Gontsarik, Mark ; Salentinig, Stefan

    In: Frontiers in Bioengineering and Biotechnology, 2019, vol. 7, p. -

    Krill oil represents an important alternative natural source of omega-3 (ω-3) polyunsaturated fatty acids (PUFAs). Considering the beneficial health effects of these essential fatty acids, particularly in various disorders including cancer, cardiovascular, and inflammation diseases, it is of paramount importance to gain insight into the digestibility of krill oil. In this work, we study the...

    Université de Fribourg

    pH-responsive nano-self-assemblies of the anticancer drug 2-hydroxyoleic acid

    Prajapati, Rama ; Gontsarik, Mark ; Yaghmur, Anan ; Salentinig, Stefan

    In: Langmuir, 2019, vol. 35, no. 24, p. 7954–7961

    pH-responsive lipid nanocarriers have the potential to selectively target the acidic extracellular pH environment of cancer tissues and may further improve the efficacy of chemotherapeutics by minimizing their toxic side-effects. Here, we present the design and characterization of pH-sensitive nano-self-assemblies of the poorly water-soluble anticancer drug 2-hydroxyoleic acid (2OHOA) with...