In: Journal of Controlled Release, 2017, vol. 264, no. Supplement C, p. 14–23
Liposomes formulated from the 1,3-diamidophospholipid Pad-PC-Pad are shear- responsive and thus promising nano-containers to specifically release a vasodilator at stenotic arteries. The recommended preclinical safety tests for therapeutic liposomes of nanometer size include the in vitro assessment of complement activation and the evaluation of the associated risk of complement...
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In: Macromolecular Materials and Engineering, 2017, p. -
The direct injection of a drug into a joint can relieve osteoarthritic pain for a short period of time. The problem is that the drug will not stay at the allocated location. Therefore, a proof-of-concept in situ is designed forming hydrogel containing liposomes that are covalently linked to the hydrogel network. When the liposomes are filled with a cargo, the formed hydrogel is thus loaded...
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In: CHIMIA International Journal for Chemistry, 2013, vol. 67, no. 11, p. 819–821
The accurate measurement of the phosphate content of a liposomal suspension is important when working with differential scanning calorimetry. Standard phosphate tests date back several decades and require extended hands-on time. Here, we present a rapid version of a phosphate test taking advantage of microwave-assisted chemical digestion and multiwell plate reading technology allowing for the...
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