Kühne, Caroline - Suchergebnisse

RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of flagellar synthesis in Salmonella enterica: Repression of flhDC transcription by a RcsB-RflM complex

Kühne, Caroline ; Singer, Hanna M. ; Grabisch, Eva ; Codutti, Luca ; Carlomagno, Teresa ; Scrima, Andrea ; Erhardt, Marc

In: Molecular Microbiology, 2016, p. -

The bacterial flagellum enables directed movement of Salmonella enterica towards favorable conditions in liquid environments. Regulation of flagellar synthesis is tightly controlled by various environmental signals at transcriptional and post- transcriptional levels. The flagellar master regulator FlhD₄C₂ resides on top of the flagellar transcriptional hierarchy and is under...

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The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC

Singer, Hanna M. ; Kühne, Caroline ; Deditius, Julia A. ; Hughes, Kelly T. ; Erhardt, Marc

In: Journal of Bacteriology, 2014, vol. 196, no. 7, p. 1448–1457

Infection of intestinal epithelial cells is dependent on the Salmonella enterica serovar Typhimurium pathogenicity island 1 (Spi1)-encoded type III injectisome system and flagellar motility. Thus, the expression of virulence and flagellar genes is subject to tight regulatory control mechanisms in order to ensure the correct spatiotemporal production of the respective gene products. In this work,...

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