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Università della Svizzera italiana

CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons

Abe, Philipp ; Mueller, Wiebke ; Schütz, Dagmar ; MacKay, Fabienne ; Thelen, Marcus ; Zhang, Penglie ; Stumm, Ralf

In: Development, 2014, vol. 141, no. 9, p. 1857-1863

The CXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron precursors in the developing cerebral cortex. Two CXCR7-mediated functions were proposed in this process: direct modulation of β-arrestin-mediated...

Consortium of Swiss Academic Libraries

Automated GUI performance testing

Adamoli, Andrea ; Zaparanuks, Dmitrijs ; Jovic, Milan ; Hauswirth, Matthias

In: Software Quality Journal, 2011, vol. 19, no. 4, p. 801-839

Università della Svizzera italiana

Learning about beta : Time-varying factor loadings, expected returns, and the conditional CAPM

Adrian,Tobias ; Franzoni, Francesco

In: Journal of empirical finance, 2009, vol. 16, no. 4, p. 537-556

We amend the conditional CAPM to allow for unobservable long-run changes in risk factor loadings. In this environment, investors rationally “learn” the long-run level of factor loadings from the observation of realized returns. As a consequence of this assumption, we model conditional betas using the Kalman filter. Because of its focus on low-frequency variation in betas, our approach...

Università della Svizzera italiana

ICT and gamified learning in tourism education : a case of South African secondary schools

Adukaite, Asta ; Cantoni, Lorenzo (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2016 ; 2016COM012.

Tourism is often introduced as a subject in formal education curricula because of the increasing and significant economic contribution of the tourism industry to the private and public sector. This is especially the case in emerging economies in Asia and Africa (Hsu, 2015; Mayaka Cuffy et al., 2012). Tourism in South Africa – which is the geographical setting of this research...

Università della Svizzera italiana

Higher-order connections between stereotyped subsets : implications for improved patient classification in CLL

Agathangelidis, Andreas ; Chatzidimitriou, Anastasia ; Gemenetzi, Katerina ; Giudicelli, Veronique ; Karypidou, Maria ; Plevova, Karla ; Davis, Zadie ; Yan, Xiao-Jie ; Jeromin, Sabine ; Schneider, Christof ; Bredo-Pedersen, Lone ; Tschumper, Renee C. ; Sutton, Lesley-Ann ; Baliakas, Panagiotis ; Scarfò, Lydia ; van Gastel, Ellen J. ; Armand, Marine ; Tausch, Eugen ; Biderman, Bella ; Baer, Constance ; Bagnara, Davide ; Navarro, Alba ; Langlois de Septenville, Anne ; Guido, Valentina ; Mitterbauer-Hohendanner, Gerlinde ; Dimovski, Aleksandar ; Brieghel, Christian ; Lawless, Sarah ; Meggendorfer, Manja ; Braazdilova, Kamila ; Ritgen, Matthias ; Facco, Monica ; Tresoldi, Cristina ; Visentin, Andrea ; Patriarca, Andrea ; Catherwood, Mark ; Bonello, Lisa ; Sudarikov, Andrey ; Vanura, Katrina ; Roumelioti, Maria ; Skuhrova-Francova, Hana ; Moysiadis, Theodoros ; Veronese, Silvio ; Giannopoulos, Krzysztof ; Mansouri, Larry ; Karan-Djurasevic, Teodora ; Sandaltzopoulos, Raphael ; Bödör, Csaba ; Fais, Franco ; Kater, Arnon ; Panovska, Irina ; Rossi, Davide ; Alshemmari, Salem ; Panagiotidis, Panagiotis ; Costeas, Paul ; Espinet Solà, Blanca ; Antic, Darko ; Foroni, Letizia ; Montillo, Marco ; Trentin, Livio ; Stavroyianni, Niki ; Gaidano, Gianluca ; Francia di Celle, Paola ; Niemann, Carsten ; Campo, Elias ; Anagnostopoulos, Achilles ; Pott, Christiane ; Fischer, Kirsten ; Hallek, Michael ; Oscier, David ; Stilgenbauer, Stephan ; Haferlach, Claudia ; Jelinek, Diane ; Chiorazzi, Nicholas ; Pospisilova, Sarka ; Lefranc, Marie-Paule ; Kossida, Sofia ; Langerak, Anton W. ; Belessi, Chrysoula ; Davi, Frederic ; Rosenquist, Richard ; Ghia, Paolo ; Stamatopoulos, Kostas

In: Blood, 2020, vol. 137, no. 10, p. 1365–1376

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients with (quasi)identical, stereotyped B cell receptor immunoglobulins (BcR IG). Patients in certain major stereotyped subsets often display remarkably consistent clinicobiological profiles, suggesting that the study of BcR IG stereotypy in CLL has important implications for understanding disease...

Università della Svizzera italiana

End-user development of mashups using live natural language programming

Aghaee, Saeed ; Pautasso, Cesare (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2014 ; 2014INFO002.

The emergence of the long-tail in the market of software applications is shifting the role of end-users from mere consumers to becoming developers of applications addressing their unique, personal, and transient needs. On the Web, a popular form of such applications is called mashup, built out of the lightweight composition of Web APIs (reusable software components delivered as a service...

Università della Svizzera italiana

Software documentation : automation and challenges

Aghajani, Emad ; Lanza, Michele (Dir.) ; Bavota, Gabriele (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO014.

Despite the undeniable practical benefits of documentation during software development and evolution activities, its creation and maintenance is often neglected, leading to inadequate and even inexistent documentation. Thus, it is not unusual for developers to deal with unfamiliar code they have difficulties in comprehending. Browsing the official documentation, or accessing online resources,...

Università della Svizzera italiana

Managing the trade-off between groundwater resources and large-scale agriculture : the case of pistachio production in Iran

Akhavan, Ali ; Gonçalves, Paulo

In: System dynamics review, 2021, vol. 37, no. 2-3, p. 155-196

Benefiting from historically favorable conditions (e.g. low costs, fertile land, and abundant water), pistachio producers in Rafsanjan, Iran, have flourished, with pistachio orchards and production growing dramatically since the 1970s. Today, however, the enormous increase in water consumption associated with pistachio production has severely depleted groundwater aquifers, causing widespread...

Università della Svizzera italiana

Response of residential electricity demand to price : the effect of measurement error

Alberini, Anna ; Filippini, Massimo

In: Energy economics, 2011, vol. 33, no. 5, p. 889-895

In this paper we present an empirical analysis of the residential demand for electricity using annual aggregate data at the state level for 48 US states from 1995 to 2007. Earlier literature has examined residential energy consumption at the state level using annual or monthly data, focusing on the variation in price elasticities of demand across states or regions, but has failed to recognize...

Università della Svizzera italiana

Survey on the design of gamified systems for energy and water sustainability

Albertarelli, Spartaco ; Fraternali, Piero ; Herrera, Sergio ; Melenhorst, Mark ; Novak, Jasminko ; Pasini, Chiara ; Rizzoli, Andrea-Emilio ; Rottondi, Cristina

In: Games, 2018, vol. 9, no. 3, p. 38

In a world affected by the constant growth and concentration of the population in urban areas, the problem of preserving natural resources has become a priority. A promising approach to resource conservation is demand management, i.e., the ability to positively influence the behaviour of the population towards more sustainable consumption. Information and Communication Technology (ICT) tools...