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Université de Fribourg

PKA-chromatin association at stress responsive target genes from Saccharomyces cerevisiae

Baccarini, Leticia ; Martínez-Montañés, Fernando ; Rossi, Silvia ; Proft, Markus ; Portela, Paula

In: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2015, vol. 1849, no. 11, p. 1329–1339

Gene expression regulation by intracellular stimulus-activated protein kinases is essential for cell adaptation to environmental changes. There are three PKA catalytic subunits in Saccharomyces cerevisiae: Tpk1, Tpk2, and Tpk3 and one regulatory subunit: Bcy1. Previously, it has been demonstrated that Tpk1 and Tpk2 are associated with coding regions and promoters of target genes in a carbon...