Université de Fribourg

Dissemination of multiresistant Enterobacter cloacae isolates producing OXA-48 and CTX-M-15 in a Spanish hospital

Fernández, Javier ; Montero, Ignacio ; Martínez, Óscar ; Fleites, Ana ; Poirel, Laurent ; Nordmann, Patrice ; Rodicio, M. Rosario

In: International Journal of Antimicrobial Agents, 2015, vol. 46, no. 4, p. 469–474

Twenty-one multiresistant Enterobacter cloacae isolates producing OXA-48 (n = 10), CTX-M-15 (n = 7) or both (n = 4) β-lactamases were detected in a Spanish hospital during a 1-year period (June 2013 to June 2014). The isolates were also resistant to non-β-lactam antimicrobials, further complicating the therapeutic options. Genotyping of the isolates...

Université de Fribourg

Multiple colonization with highly resistant bacteria: carbapenemase-producing Enterobacteriaceae, carbapenemase-producing Pseudomonas aeruginosa, carbapenemase-producing Acinetobacter baumannii, and glycopeptide-resistant Enterococcus faecium

Girlich, Delphine ; Nordmann, Patrice ; Lécuyer, Hervé ; Berche, Patrick ; Marmorat-Khuong, Anne ; Gros, Isabelle ; Cuzon, Gaëlle ; Dortet, Laurent

In: Diagnostic Microbiology and Infectious Disease, 2015, p. -

The dissemination of carbapenemase-producing bacteria worldwide is an important source of concern because carbapenemase producers are multidrug resistant (Nordmann and Poirel, 2014). National guidelines increasingly recommend a systematic screening of at least carbapenemase-producing Enterobacteriaceae (CPE) and glycopeptide-resistant enterococci (GRE) in patients admitted to hospitals who have...

Université de Fribourg

KPC-producing Klebsiella pneumoniae, finally targeting Turkey

Labarca, Jaime ; Poirel, Laurent ; Özdamar, M. ; Turkoglü, S. ; Hakko, E. ; Nordmann, Patrice

In: New Microbes and New Infections, 2014, vol. 2, no. 2, p. 50–51

We report here the first identification of the worldwide spread of Klebsiella pneumoniae carbapenemase-2-producing and carbapenem-resistant K. pneumoniae clone ST258 in Turkey, a country where the distantly-related carbapenemase OXA-48 is known to be endemic. Worryingly, this isolate was also resistant to colistin, now considered to be the last-resort antibiotic for carbapenem-resistant isolates.

Université de Fribourg

Carbapenemase-producing Enterobacteriaceae: Overview of a major public health challenge = Entérobactéries et carbapénémases : bilan et enjeux d’un problème de santé publique majeur

Nordmann, Patrice

In: Médecine et Maladies Infectieuses, 2014, vol. 44, no. 2, p. 51–56

Bacterial resistance to antibiotics has become a major source of concern for public health. Enterobacteriaceae are among the most common human pathogens, causing community-acquired as well as hospital-acquired infections. Carbapenem-resistant Enterobacteriaceae have been increasingly reported worldwide since their first identification more than 20 years ago. Three main classes of carbapenemases...