Université de Fribourg

Full genome sequence of pT3, a multiresistant plasmid carrying the mcr-3.5 colistin resistance gene, recovered from an extended-spectrum-β-lactamase-producing Escherichia coli isolate from crickets sold as food

Zurfluh, Katrin ; Stevens, Marc J. A. ; Bucher, Melissa ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Microbiology Resource Announcements, 2019/8/29/e00647-19, /mra/8/29/MRA.00647-19.atom

Here, we sequenced multidrug resistance plasmid pT3, which encodes mcr-3.5 and other resistance genes. The cooccurrence of mcr genes and other resistance genes on a single plasmid is of concern.

Université de Fribourg

Key features of mcr-1-bearing plasmids from Escherichia coli isolated from humans and food

Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena ; Klumpp, Jochen ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 91

Mcr-1-harboring Enterobacteriaceae are reported worldwide since their first discovery in 2015. However, a limited number of studies are available that compared full-length plasmid sequences of human and animal origins.

Université de Fribourg

Screening for fecal carriage of MCR-producing Enterobacteriaceae in healthy humans and primary care patients

Zurfluh, Katrin ; Stephan, Roger ; Widmer, Andreas ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch, Hans-Jakob ; Hächler, Herbert ; Nüesch-Inderbinen, Magdalena

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 28

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...

Université de Fribourg

Emergence of Escherichia coli producing OXA-48 β-lactamase in the community in Switzerland

Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena T ; Poirel, Laurent ; Nordmann, Patrice ; Hächler, Herbert ; Stephan, Roger

In: Antimicrobial Resistance and Infection Control, 2016, vol. 4, p. 9

The emergence and worldwide spread of carbapenemase-producing Enterobacteriaceae is of great concern to public health services. The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae in the community in Switzerland.Findings: One thousand and eighty-six stool samples of healthy humans (staff members of a food-processing company which were screened...