In: Proceedings of the Nutrition Society, 2012, vol. 71, no. 3, p. 379-389
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In: European Journal of Clinical Nutrition, 2017, vol. 71, no. 3, p. 353–357
While putative feedback signals arising from adipose tissue are commonly assumed to provide the molecular links between the body’s long-term energy requirements and energy intake, the available evidence suggests that the lean body or fat-free mass (FFM) also plays a role in the drive to eat. A distinction must, however, be made between a ‘passive’ role of FFM in driving energy intake,...
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In: Obesity Reviews, 2015, vol. 16, p. 25–35
Whether dieting makes people fatter has been a subject of considerable controversy over the past 30 years. More recent analysis of several prospective studies suggest, however, that it is dieting to lose weight in people who are in the healthy normal range of body weight, rather than in those who are overweight or obese, that most strongly and consistently predict future weight gain. This paper...
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In: Cahiers de Nutrition et de Diététique, 2013, vol. 48, no. 1, p. 15–25
‘Dieting Makes You Fat’ – the title of a book published in 1983 – embodies the notion that dieting to control body weight, with consequential weight cycling, predisposes the individual to acquire even more body fat. While this notion is controversial, its debate underscores the large gap, which exists in our understanding of basic physiological laws, which govern the regulation of human...
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In: Obesity Reviews, 2012, vol. 13, no. S2, p. 105–121
According to Lavoisier, ‘Life is combustion’. But to what extent humans adapt to changes in food intake through adaptive thermogenesis – by turning down the rate of heat production during energy deficit (so as to conserve energy) or turning it up during overnutrition (so as to dissipate excess calories) – has been one of the most controversial issues in nutritional sciences over the past...
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In: Proceedings of the Nutrition Society, 2012, p. -
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In: International Journal of Obesity, 2010, vol. 34, p. S4–S17
Dynamic changes in body weight have long been recognized as important indicators of risk for debilitating diseases. While weight loss or impaired growth can lead to muscle wastage, as well as to susceptibility to infections and organ dysfunctions, the development of excess fat predisposes to type 2 diabetes and cardiovascular diseases, with insulin resistance as a central feature of the disease...
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In: International Journal of Obesity, 2006, vol. 30, no. S4, p. S23–S35
The analyses of large epidemiological databases have suggested that infants and children who show catch-up growth, or adiposity rebound at a younger age, are predisposed to the development of obesity, type 2 diabetes and cardiovascular diseases later in life. The pathophysiological mechanisms by which these growth trajectories confer increased risks for these diseases are obscure, but there is...
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In: Physiology & Behavior, 2004, vol. 83, no. 4, p. 587-602
After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a...
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