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Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii

Arsenijevic, Denis ; Bilbao, F. de ; Vallet, Philippe ; Hemphill, Andrew ; Gottstein, B. ; Richard, Denis ; Giannakopoulos, Panteleimon ; Langhans, Wolfgang

In: Neuroscience, 2007, vol. 150, no. 3, p. 537-546

To determine whether Toxoplasma gondii infection could modify biological phenomena associated with brain ischemia, we investigated the effect of permanent middle cerebral artery occlusion (MCAO) on neuronal survival, inflammation and redox state in chronically infected mice. Infected animals showed a 40% to 50% decrease of infarct size compared with non-infected littermates 1, 4 and 14 days after...