In: ChemMedChem, 2014, vol. 9, no. 6, p. 1221-1230
Materials foreign to the body are used ever more frequently, as increasing numbers of patients require implants. As a consequence, the numbers of implant-related infections have grown as well, and with increasing resistance. Treatments often fail; thus, new antibacterial coating strategies are being developed by scientists to avoid, or at least strongly reduce, bacterial adhesion to implant...
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In: Polymers, 2018, vol. 10, no. 6, p. 665
In this study, four trithiocarbonate-functionalized PNiPAAms with different molecular weights were synthesized and used as a matrix to form composites with silver nanoparticles. Nanocomposites with several polymer-to-silver ratios P:Ag+ were prepared in order to evaluate the influence of silver loading. UV studies showed a thermoresponsive behavior of the nanocomposites with a...
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In: Nanomedicine: Nanotechnology, Biology and Medicine, 2017, vol. 13, no. 1, p. 11–22
The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding...
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In: Polymers, 2016, vol. 8, no. 6, p. 208
Polyether ether ketone (PEEK) is a well-known polymer used for implants and devices, especially spinal ones. To overcome the biomaterial related infection risks, 4-4′- difluorobenzophenone, the famous PEEK monomer, was modified in order to introduce binding sites for silver ions, which are well known for their antimicrobial activity. The complexation of these new monomers with different...
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In: Antimicrobial Agents and Chemotherapy, 2016, p. AAC.02934–15
Implant-associated infections (IAI) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium aluminium niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-dependent activity against Staphylococcus (S.) epidermidis and S. aureus in an...
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In: Comptes Rendus Chimie, 2013, vol. 16, no. 6, p. 550–556
A silver polystyrene sulfonate polyelectrolyte was synthesized, showing a spontaneous reduction of silver ions to silver nanoparticles over a period of approximately 1 month. A follow-up of the nanoparticle formation via scanning electron microscopy (SEM) reveals migration of the nanoparticles towards the cracks of the polymer over time, leading to a self-healing process of the nanocomposite....
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In: Chemical Reviews, 2013, vol. 113, no. 7, p. 4708–4754
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In: Dalton Transactions, 2013, vol. 42, no. 1, p. 217-231
Complexes with silver ions have great potential for applications in medicine. Appropriate bidentate ligands, binding to silver ions, are able to generate coordination polymers as well as molecular entities as a function of ligand flexibility, conformation and length. Here we present the continuation of our previous studies in this field with ligands based on oligomers of polyethylene glycol,...
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In: Materials, 2011, vol. 4, no. 2, p. 355-367
Biofilm formation on implant materials causes a common problem: resistance to aggressive pharmacological agents as well as host defenses. Therefore, to reduce bacterial adhesion to implant surfaces we propose to use silver(I) coordination networks as it is known that silver is the most powerful antimicrobial inorganic agent. As a model surface, self-assembled monolayers (SAMs) on gold Au(111) was...
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In: Antimicrobial Agents and Chemotherapy, 2010, vol. 54, no. 10, p. 4208-4218
Prosthetic joint replacements are used increasingly to alleviate pain and improve mobility of the progressively older and more obese population. Implant infection occurs in about 5% of patients and entails significant morbidity and high social costs. It is most often caused by staphylococci, which are introduced perioperatively. They are a source of prolonged seeding and difficult to treat...
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