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Université de Fribourg

Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens

Adriani, W. ; Boyer, Frederic ; Gioiosa, L. ; Macrì, S. ; Dreyer, Jean-Luc ; Laviola, G.

In: Neuroscience, 2009, vol. 159, no. 1, p. 47-58

Multiple theories have been proposed for sensation seeking and vulnerability to impulse-control disorders [Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: Common biosocial factors. J Pers 68:999–1029], and many of these rely on a dopamine system deficit. Available animal models reproduce only some behavioral symptoms and seem devoid of construct validity. We used lentivirus tools...

Université de Fribourg

Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens

Adriani, Walter ; Boyer, Frederic ; Leo, Damiana ; Canese, Rossella ; Podo, Franca ; Perrone-Capano, Carla ; Dreyer, Jean-Luc ; Laviola, Giovanni

In: The International Journal of Neuropsychopharmacology, 2010, p. -

Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil)....

Université de Fribourg

Drosophila suzukii: the genetic footprint of a recent, world-wide invasion

Adrion, Jeffrey R. ; Kousathanas, Athanasios ; Pascual, Marta ; Burrack, Hannah J. ; Haddad, Nick M. ; Bergland, Alan O. ; Machado, Heather ; Sackton, Timothy B. ; Schlenke, Todd A. ; Watada, Masayoshi ; Wegmann, Daniel ; Singh, Nadia D.

In: Molecular Biology and Evolution, 2014, p. msu246

Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here we investigate the genetic population structure of this invasive fruit fly, with a focus on the eastern United States. We...

Université de Fribourg

Apex predators decline after an influx of pastoralists in former Central African Republic hunting zones

Aebischer, Thierry ; Ibrahim, Tidjani ; Hickisch, Raffael ; Furrer, Roman D. ; Leuenberger, Christoph ; Wegmann, Daniel

In: Biological Conservation, 2020, vol. 241, p. 108326

Pastoralism is spreading in Central Africa, where many protected areas are under consideration to be opened for grazing, in particular hunting zones. Here we document the loss of biodiversity followed by an influx of transhumant pastoralism into previously uninhabited and virtually pristine habitat in the Central African Republic. Our track count and camera trap surveys of 2012, 2016 and...

Université de Fribourg

First quantitative survey delineates the distribution of chimpanzees in the Eastern Central African Republic

Aebischer, Thierry ; Siguindo, Guy ; Rochat, Estelle ; Arandjelovic, Mimi ; Heilman, Amy ; Hickisch, Raffael ; Vigilant, Linda ; Joost, Stéphane ; Wegmann, Daniel

In: Biological Conservation, 2017, vol. 213, no. Part A, p. 84–94

Vast, pristine ecosystems and their biodiversity are vanishing globally at frightening speed, but many large tracts of wilderness have not yet been systematically inventoried and important natural populations of threatened species remain poorly characterized. The forest-savanna ecotone of the Eastern Central African Republic (CAR) is one such poorly studied area. Using camera traps, transect...

Université de Fribourg

Large-scale comparison of toxin and antitoxins in Listeria monocytogenes

Agüero, José Antonio ; Akarsu, Hatice ; Aguilar-Bultet, Lisandra ; Oevermann, Anna ; Falquet, Laurent

In: Toxins, 2020, vol. 12, no. 1, p. 29

Toxin–antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in Listeria monocytogenes (Lm), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania...

Université de Fribourg

Genetic separation of Listeria monocytogenes causing central nervous system infections in animals

Aguilar-Bultet, Lisandra ; Nicholson, Pamela ; Rychener, Lorenz ; Dreyer, Margaux ; Goezel, Bulent ; Origgi, Francesco C. ; Oevermann, Anna ; Frey, Joachim ; Falquet, Laurent

In: Frontiers in Cellular and Infection Microbiology, 2018, vol. 8, p. -

Listeria monocytogenes is a foodborne pathogen that causes abortion, septicemia, gastroenteritis and central nervous system (CNS) infections in ruminants and humans. L. monocytogenes strains mainly belong to two distinct phylogenetic groups, named lineages I and II. In general, clinical cases in humans and animals, in particular CNS infections, are caused by lineage I strains, while most of...

Université de Fribourg

Draft Genome sequence of the virulent avibacterium paragallinarum serotype a strain JF4211 and identification of two toxins

Aguilar-Bultet, Lisandra ; Calderon-Copete, Sandra P. ; Frey, Joachim ; Falquet, Laurent

In: Genome Announcements, 2013, vol. 1, no. 4, p. e00592-13

Avibacterium paragallinarum is an important pathogen of chicken livestock causing infectious coryza. Here, we report the draft genome sequence of the virulent A. paragallinarum serotype A strain JF4211 (2.8 Mbp and G+C content of 41%) and the two toxin operons discovered from the annotation of the genome.